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1. part of a yam that is near the ankle and extremely large and disgusting Adam and Derek are such yamshankles..

1. When you're constantly sick and complaining about a variety of things, mainly back pains. Yo, that muthafucka called me to take hi..

1. It's just a word that has a exaggerating tone to it that makes it funny sounding and at the same time saying "Don't F***e..