Drunk As Ten Indians Edit Meaning

1.

Native American populations are plagued by a mutation of the gene for the enzyme aldehyde dehydrogenase, which plays a major role in metabolizing alcohol. This mutation leads the poor metabolism of alcohol; thus increasing alcohol’s toxicity

Timmy hasn’t eaten today so he got drunk as ten Indians.

See drunk as a bicycle, plastered, wasted, hammerd, trashed, fucked up, loaded, alcoholic, fubar