What is D-up?
1.
To give a blowjob or act slutty. To give head to anyone when intoxicated just to make people think you are sexually advanced and cool.
That chick d you up?
or
Yo, cmhere and d me up.
or
Dawg she always wants to d-up at every party.
See 
2.
defense
cops are coming
See 
3.
To take a shit, do the duece
Are you goin in there to d-up? or, Smells like somebody went d-up in there.
See 
Random Words:
1. 
A particular set of circumstances in which one has a deficient amount of body fat causing them to look like a Nazi concentration camp te..