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To be in a continual state of depression, to the extent of general apathy, loss of self-worth and astronomical standard setting.
Other ..
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a woman who will go crazy over her wedding, stressing and running around organising everything making sure everything is ok for her big ..
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A variant of 'hows your father?' The origins of the phrase are obscure at best. To 'have a bit of hows your Minkton'..