What is P.n.s.?
Pre-Nicotine Syndrome. Describes the bitchy, cranky, irritable mindstate prior to having the day's first cigarette.
Why don't you go have a smoke instead of acting like a P.N.S.ing bitch?
Puffy Nipple Syndrome.
Jay: Luke, you have a little too much PNS going on today!
Luke: Aw, man... I really need to do pushups to get rid of these bitch tits.
Jay: Lets go look at porn.