What is P.o.e.?
1.
acronym.
pills over everything
"Yo man, did you check out crazy e's new tattoo?"
"He got P.O.E., pills over everything, nigga!"
See 
2.
acronym for "Pussy Over Everythang"
"When it comes to these hoes, P.O.E. nigga"
See 
3.
acronym for "pussy over everything"
When it comes to these hoes, P.O.E. nigga.
See 
Random Words:
1. 
The time from 1933 to 1945 when Hitlerand the Nazis controlled Germany. The Nazis were very racist towards Jews and removed their rights..