This is a horrible autoimmune disease. It mostly effects joint, but can effect other organs. The disease usually begins gradually with fatigue, morning stiffness (lasting more than one hour), widespread muscle aches, loss of appetite, and weakness. Eventually, jointpain appears. When the jointis not used for a while, it can become warm, tender, and stiff. When the lining of the joint(synovium) becomes inflamed, it gives off more fluid and the jointbecomes swollen. Jointpain is often felt on both sides of the body, and may effect the wrist, knees, elbows, fingers, toes, ankle or neck.