What is Run Up On?
1.
to confront someone with hostility
so then she gonna run up on me talkin about i owe her some money.
2.
to 
so what make's you think imma run up on you with a nine
-50 Cent
3.
To try to make a move or have sex with somebody
"Whaddup with you and me girl? When we gon' chill?"
"Nigga,Dont even try to run up on my shit!!"
See 
Random Words:
1. 
When you handle your life properly, good things happen. You would be "doin it big."
Damn your girl is fine!
Yezzir, I'm..