What is 2p1s?
A hand gesture that implies that one has, will or would like to indulge in the act of placing 2 in the pink and one in the stink.
Hey dude wouldn't you like to do the old (Show Hand Gesture) to that nasty piece of work over there.
2 to the pink pussy
1 to the stink ass
2P1S Kick Ass Totally!