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A combination of a queef and a dingleberry
Mark: You're dumb!
Mike: Shut up you queefberry!
See insult, dis, queef, berry, dingl..
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The term describes something that is exceptional, or awesome. It is derived from "pwn" which is ultimate nerd internet ownage...
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(loo-pus) n - Abbreviated form for Lazy, Useless, Piece of Shit.
Ernest is such a L.U.P.O.S., all he does is sleep all day.
See piece ..