Three On The 21

What is Three On The 21?

In reference to Trisomy 21 where there is 3 genetic materials on the 21st chromosome instead of the usual 2. This causes Down's Syndrome.

He never really understnads what is happening.I think he's a little 3 on the 21. Started in Canada in 2004.

Fuckhead Syndrome

1. A Syndrome denoting one's overly zealous, overly attention-seeking, overly "jock"; ultimately "over-rated" beha..

Hat Up

1. An older expression (circa 1950's) used to describe the action of leaving one's present location (see outie) "Gotta work..

Holy Buckets

1. much like "holy shit" but in the less offensive christian format "Holy buckets, Steph I haven't seen you forever!&q..

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Three On The 21 Edit Meaning