Three On The 21

What is Three On The 21?

In reference to Trisomy 21 where there is 3 genetic materials on the 21st chromosome instead of the usual 2. This causes Down's Syndrome.

He never really understnads what is happening.I think he's a little 3 on the 21. Started in Canada in 2004.

Yellow Trail

1. the act of banging a chick doggy style then pulling out and pissing in the small of her back...so when she stands it makes a trail down ..

Uziga

1. (Waita Uziga) An artist of what can be classified only as slaughter hentai, quite possibly the sickest mind to grace existance since H.R..

Zach Munger

1. guy with a 16 inch dick. I went to go have sex with him and he had a Zach munger. See big, dick, huge, weiner..

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Three On The 21 Edit Meaning