Three On The 21

What is Three On The 21?

In reference to Trisomy 21 where there is 3 genetic materials on the 21st chromosome instead of the usual 2. This causes Down's Syndrome.

He never really understnads what is happening.I think he's a little 3 on the 21. Started in Canada in 2004.

Tuck-it-forward

1. To show some "balls" or to show that you have courage during a time of stress, anxiety, or pressure. It is derived from doing ..

Grandpa

1. and old fogey who knows his shit. totally gangsta. lol "im bout it, im rowdy, i just passed a kidney stone." See sketch 2. ..

Kankle-monster

1. VD-Encrusted fat chick who has not only large folds of fat hanging over ankles and knees, but also elbows. Frequently seen at fast-food..

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Three On The 21 Edit Meaning