Three On The 21

What is Three On The 21?

In reference to Trisomy 21 where there is 3 genetic materials on the 21st chromosome instead of the usual 2. This causes Down's Syndrome.

He never really understnads what is happening.I think he's a little 3 on the 21. Started in Canada in 2004.

Up Your Butt

1. Another way of saying screw you, fuck you, etc. Can also be used as, "Up your ass." Guy #1: Your girlfriend is ugly as butt...

Jackson Burger

1. A 40 year old piece of meat between two 12 year old buns. yo that jackson burger is some sick shit...

Uncle Jesse And The Olsen Twins

1. less better than Ratslayer and the crackerjack horse killers! Ratslayer and the crackerjack horse killers are infact not uncle jesse an..

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Three On The 21 Edit Meaning