Three On The 21

What is Three On The 21?

In reference to Trisomy 21 where there is 3 genetic materials on the 21st chromosome instead of the usual 2. This causes Down's Syndrome.

He never really understnads what is happening.I think he's a little 3 on the 21. Started in Canada in 2004.

Zizza

1. Weed or to smoke weed. "Hey, bro, lets grab some zizza on the way to the Umphrey's show." "Sure thing, man." ..

Opossum Drop

1. A male masterbating while hanging upside down, trying to catch the cum in his mouth on the way down. I don't use my pull up bar fo..

Jake Buk

1. a young fellow who will cock block you with the sheer power of his mind. and he also has a pretty big dick dude, jimy totally pulled a ..

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Three On The 21 Edit Meaning