Three On The 21

What is Three On The 21?

In reference to Trisomy 21 where there is 3 genetic materials on the 21st chromosome instead of the usual 2. This causes Down's Syndrome.

He never really understnads what is happening.I think he's a little 3 on the 21. Started in Canada in 2004.

Jellydonut

1. when you get head from a girl, you come in her mouth and then you punch her in the mouth, so her lips swell and come and blood dribble o..

Swedish Softserve

1. The act of a man dropping a nice cold scoop of ice cream of any flavor into his partners vagina and then plowing her from behind. After ..

Richter It Up

1. The act of screwing something up after bragging about how great you are at it. Usually used in a derogatory sense. Present tense: &qu..

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Three On The 21 Edit Meaning