Three On The 21

What is Three On The 21?

In reference to Trisomy 21 where there is 3 genetic materials on the 21st chromosome instead of the usual 2. This causes Down's Syndrome.

He never really understnads what is happening.I think he's a little 3 on the 21. Started in Canada in 2004.

Zesty

1. adjective used to describe someone that has done something gay. You got on a pink shirt!? You ol' zesty ass nigga! See zesty, gay..

Coffee Maker

1. 1. Cup of coffee with cum in it given to a woman after sex. 2. Cumming in your hand and then slowly dripping it onto the woman. 3. Slo..

Apryl Beck

1. The most gorgeous and wonderful BITCH you will EVER MEET; loquacios Apryl Beck is so beautiful, but so bitchy See beautiful..

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Three On The 21 Edit Meaning