Three On The 21

What is Three On The 21?

In reference to Trisomy 21 where there is 3 genetic materials on the 21st chromosome instead of the usual 2. This causes Down's Syndrome.

He never really understnads what is happening.I think he's a little 3 on the 21. Started in Canada in 2004.

Laaaarrrrrrrry!

1. 1. (Noun) A well-known chant of New York Mets fans in a futile attempt to disrupt Atlanta Braves slugger Chipper Jones at the plate. 2...

Heej/beej Combo

1. when a girl moves her hand while giving a beej for added effect. also giving a hj intermittently so she can take a break from all the b..

Effed Up

1. (adj) Remark about something that is fucked up when fucked up isn't cool enough, can't be said aloud without a parental shitst..

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Three On The 21 Edit Meaning