Three On The 21

What is Three On The 21?

In reference to Trisomy 21 where there is 3 genetic materials on the 21st chromosome instead of the usual 2. This causes Down's Syndrome.

He never really understnads what is happening.I think he's a little 3 on the 21. Started in Canada in 2004.

Dutch Pillow

1. Derived from a popular and crude sexual maneuver practiced in the heavily Dutch area of Grand Rapids, Michigan. This involves anallingus..

Madame Muffin

1. A girl who insists on wearing shirts that are absurdly tight and skinny jeans, resulting in an "extreme" muffin top. I swear..

Goatsquatch

1. 1) a very ugly person; looks like half goat, half sasquatch 2) the taint, the tweenis, the grundle 1) Bob: "Wow. Did you see that..

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Three On The 21 Edit Meaning