Three On The 21

What is Three On The 21?

In reference to Trisomy 21 where there is 3 genetic materials on the 21st chromosome instead of the usual 2. This causes Down's Syndrome.

He never really understnads what is happening.I think he's a little 3 on the 21. Started in Canada in 2004.

Valtek1

1. A god dam ownage runescape player Valtek1 k0ed me with a 1 omg See valtek1, val, ownage, amazing..

Sherly

1. A big loser with awesome style. They may also talk like a prep. Wow! Look at that girl. She's such a Sherly...

Zyxes

1. Sexy to the thirtieth power. Etymology: sexy backwards with a z in it. Dude, I saw Melissa the other day. She was lookin pretty freak..

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Three On The 21 Edit Meaning