Three On The 21

What is Three On The 21?

In reference to Trisomy 21 where there is 3 genetic materials on the 21st chromosome instead of the usual 2. This causes Down's Syndrome.

He never really understnads what is happening.I think he's a little 3 on the 21. Started in Canada in 2004.

Nigeeta

1. a black female or nigga who talks a lot or is disturbing; a black girl that is ugly Damn man, I just saw a huge nigeeta and she was sic..

Vip Bun-bun

1. A 'COOL' drink to make ye crunk in da club hustla. The drink is made of 4 parts malibu rum 3 parts pineapple juice and one hal..

Reverse Roxanne

1. When one cuts open their abdomen and allows a girl to give him head from the inside out. Billy: Dude you intestines are showing. Tommy..

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Three On The 21 Edit Meaning