Three On The 21

What is Three On The 21?

In reference to Trisomy 21 where there is 3 genetic materials on the 21st chromosome instead of the usual 2. This causes Down's Syndrome.

He never really understnads what is happening.I think he's a little 3 on the 21. Started in Canada in 2004.

Sunset Boulevard Look

1. Someone who always dresses in an extremely flashy manner and needs to feel like hot stuff during just about any occasion. Even when visi..

O Smile

1. Best used when making fun of some poor unsuspecting fool. When he makes his best O smile (smiling and forming a big O with the lips), yo..

Jerkburger

1. Used to describe a person when they are exhibiting rude, cruel, or manipulative behavior, at your personal expense. May be used in a pla..

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Three On The 21 Edit Meaning