Tissue Issue Edit Meaning

1.

When you need a tissue, but don't have one on your person, which then causes an issue

I almost had a tissue issue but i had a tissue in my pocket and therefore there was no issue.

See tissue, issue, tissue issue

2.

A human resource issue when someone is whining and a mock tissue to wipe the eye is necessary.

Also a human resource issue involving people rather than equipment or processes.

Are you whining? This sounds like a tissue issue.

We've got another tissue issue, the warehouse crew is bitching again.