What is Twayne?
1.
Any song featuring both Lil' Wayne and T-Pain.
Boy: Dayum Who's this beat?
Girl: It's the new joint by Twayne.
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2.
The little bugs you find in your pubic hair
Dude, stop picking twaynes off your pubes
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Random Words:
1.
Short for *you for sure, mother f*cker?*
As in, are you telling the truth??
Used by chavs etc.
A short way of asking a simple questio..