What is Tweaking?
1.
Frantic and compuslive behaviour often associated with methamphetamine abuse (crank). People who regularly abuse crank may find themselves unable to stop a particular random activity like searching drawers, having sex, or putting things apart. This is called tweaking.
"Oh man last night was awesome, I was tweaking and fucked my girlfriend for 6 hours straight..."
2.
High on meth/crank. See also "Smebbin".
I was tweaking so hard I couldn't see straight.
3.
To describe someone that is out of thier mind or making a mistake.
"Ohh did I say 6:00 o'clock? I ment 5:00, I'm tweaking!"
See
4.
To do crack or act like doing crack/cocaine.
Most of the time used in a question
"Gave who some dam money? I aint gave no nobody no damn money girl! IS YOU TWEAKING!?" By R-kelly Real Talk
See
5.
1. High on
2. High on
Dude, you are totally tweaking.
6.
To be very angry
i.e. mad, spazzing, angry
you are tweaking
Quit tweakin you tweaker