What is Twist Off?
1.
To consume alcoholic beverages. The term comes from twist off beer bottles. (verb, intransitive)
Sam is such an alcoholic that he has to wake up every couple of hours during the night to twist off because he starts to get too much blood in his alcohol stream.
"It's Friday evening 6:00 and all my friends are twistin' off." -Tracy Byrd, "Drinkin' Bone"
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2.
to punch someone.
mutha-fucka dissed me, i had to twist off on him.
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3.
to get really angry, then explode
he finally twisted off and killed the bitch
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The anus.
I had this girl over, we started fooling around, next thing you know, I'm mounting her and sticking it in her poop pocke..
1.
(verb) While in the act of sex from behind, just before orgasm you punch your partner in both eyes and stick it in her ass.
That chick ..