What is Upsyndrome?
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1. The state of one's PENIS being in a perpetual state of happiness.
"Ever since meeting Caroline, I think Tom has come down with a bout of up-syndrome."
"...It really sucks having your upsyndrome flair up at a gay bar..."
We always thought Susie was weird, then the truth reared its ugly little head -- out of her pants when she was diagnosed with up-syndrome!"
5:00 News Headline:
"Rare condition found in man with up-syndrome -- are two penises better than one?"
Random Words:
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thank you. A take off of Gracias. (Thank you in spanish)
Lauren: "Does anyone have any water?"
Nicole: "I do." (Ha.. 
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The up and down, side to side jaw movement side affect of being high cocain.
check out this cokehead over here, eaten up all the invisi.. 
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Slang term for all right.
Everything is aiiiiiight!..