You're Tearing Me Apart, Lisa Edit Meaning

1.

An expression used to indicate that someone is making a big deal out of nothing. Stolen from a line of dialogue in a bad movie, Tommy Wiseau's "The Room".

Megan: So, Will. We need to talk. It may not be important to you, but the cap on a toothpaste tube should have a tight seal. If it does not, then bacteria can manifest itself in the paste, not to mention the cap coming off and squirting toothpaste onto my clothes.

Will: (holding his head in his hands and screaming) You're tearing me apart, Lisa!

Megan: Who's Lisa?