What is Appropiate Typo?
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An example of an appropiate typo (or one which is intentional).. would be ‘Oll Korrect’, from which the confirmatory ‘OK’ is derived. Or for words from primary-source documents which are no-longer in usage (extinct), such as ‘Pleasaunce’.
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In reference to Trisomy 21 where there is 3 genetic materials on the 21st chromosome instead of the usual 2. This causes Down's Syn..