What is Big Louie?
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A generic phrase to describe any sexually transmitted disease, or as a shorthand to describe having multiple STDs. Some dispute exists as to the proper spelling, but either "Big Louie" or "Big Louis" is acceptable.
Dude, if a chick ever makes you get tested for the Big Louie, make sure to piss in the cup instead of letting them stick that huge q-tip in there, that shit hurts.
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1. a friend that is considred the bitch out of your group.
2. A name for Hitz.
3. A vagina with genital warts.
1. He is def a the Vag..
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Lining up a row of hookers, and eating their crotches out.
We got 4 hookers naked in a row, and did a vegas buffet down the line!
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A man with an asshole for a face...Don't believe me? Watch Love Guru.
Danny: You're on drugs again aren't you?
Tim: YEE..