What is Big Louie?
1.
A generic phrase to describe any sexually transmitted disease, or as a shorthand to describe having multiple STDs. Some dispute exists as to the proper spelling, but either "Big Louie" or "Big Louis" is acceptable.
Dude, if a chick ever makes you get tested for the Big Louie, make sure to piss in the cup instead of letting them stick that huge q-tip in there, that shit hurts.
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1.
A massive homosexual, or faggot as you can call them.
Haha he's such a quiff cake!
See quiff cake, cake, quiff, homo, homosexual,..
1.
When you have to return the bathroom, some time after taking a shit and initially wiping, to wipe again. This could be due to a number ..
