What is Big Louie?
1.
A generic phrase to describe any sexually transmitted disease, or as a shorthand to describe having multiple STDs. Some dispute exists as to the proper spelling, but either "Big Louie" or "Big Louis" is acceptable.
Dude, if a chick ever makes you get tested for the Big Louie, make sure to piss in the cup instead of letting them stick that huge q-tip in there, that shit hurts.
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Random Words:
1.
to almost get head, to fail to recieve head
dee: hey alare give me head
alare: no... maybe
dee: man five john i almost got head
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1.
A pair of sisters who are always stabbing eachother in the back, derived from the movie "The Other Boleyn Girl" which depicts ..