What is Big Louie?
1.
A generic phrase to describe any sexually transmitted disease, or as a shorthand to describe having multiple STDs. Some dispute exists as to the proper spelling, but either "Big Louie" or "Big Louis" is acceptable.
Dude, if a chick ever makes you get tested for the Big Louie, make sure to piss in the cup instead of letting them stick that huge q-tip in there, that shit hurts.
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1.
Someone who is whiter than a vanilla face and a cracker combined.
In short, the whiteist kid you know.
Pat: What it is vanilla cracke..
1.
fucking a girl so hard that the friction causes her vag to start smoking, then you quickly pee in her, causing a small explosion that ma..