What is Big Louie?
1.
A generic phrase to describe any sexually transmitted disease, or as a shorthand to describe having multiple STDs. Some dispute exists as to the proper spelling, but either "Big Louie" or "Big Louis" is acceptable.
Dude, if a chick ever makes you get tested for the Big Louie, make sure to piss in the cup instead of letting them stick that huge q-tip in there, that shit hurts.
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The barrier to further promotion in a business defined by a person's inability to play golf.
because i'm rubbish at golf, i&a..
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this is real helpful cause it happens all the time. A guy spends all his time tryin to get laid by this one girl just leadin him on and..