What is Big Louie?
1.
A generic phrase to describe any sexually transmitted disease, or as a shorthand to describe having multiple STDs. Some dispute exists as to the proper spelling, but either "Big Louie" or "Big Louis" is acceptable.
Dude, if a chick ever makes you get tested for the Big Louie, make sure to piss in the cup instead of letting them stick that huge q-tip in there, that shit hurts.
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a youtube account with a semi-famous video of a Chinese emo kid that cuts off his hand. The video has since recieved over ten thousand h..
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A female, not that attractive but enough "sweet" or "cute" features that you have a crush on her, but when she grows..
