What is Big Louie?
1.
A generic phrase to describe any sexually transmitted disease, or as a shorthand to describe having multiple STDs. Some dispute exists as to the proper spelling, but either "Big Louie" or "Big Louis" is acceptable.
Dude, if a chick ever makes you get tested for the Big Louie, make sure to piss in the cup instead of letting them stick that huge q-tip in there, that shit hurts.
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1.
To become a nerd for a temporary amount of time e.g. to study intensively.
Can be abbreviated as NIU.
Person A: Hey don't you hav..
1.
When you and yo bitch are fuckin and you whip out a fried chicken drumstick and shove it up her ass and pound her ass with it, then pull..