What is Big Louie?
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A generic phrase to describe any sexually transmitted disease, or as a shorthand to describe having multiple STDs. Some dispute exists as to the proper spelling, but either "Big Louie" or "Big Louis" is acceptable.
Dude, if a chick ever makes you get tested for the Big Louie, make sure to piss in the cup instead of letting them stick that huge q-tip in there, that shit hurts.
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n. the blonde whiteboy playa from Saved By The Bell. That dude was crazy!
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When someone desides to take there time and search around Youtube. Looking into the depts of the website, the youtuber will find what t..