What is Big Louie?
1.
A generic phrase to describe any sexually transmitted disease, or as a shorthand to describe having multiple STDs. Some dispute exists as to the proper spelling, but either "Big Louie" or "Big Louis" is acceptable.
Dude, if a chick ever makes you get tested for the Big Louie, make sure to piss in the cup instead of letting them stick that huge q-tip in there, that shit hurts.
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1.
The act of waking a significant other shortly before spewing a load of cum on their face.
*nudge* *nudge*
Psst... Hey Megan, wake up! ..
1.
Chain reaction that happens when the driver in front of you on the freeway cleans their windshield, spraying droplets of screenwash onto..
1.
the state of being grouchy or a party-pooper
You have a particularly large 'coon in your pants!
See downer..
