What is Big Louie?
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A generic phrase to describe any sexually transmitted disease, or as a shorthand to describe having multiple STDs. Some dispute exists as to the proper spelling, but either "Big Louie" or "Big Louis" is acceptable.
Dude, if a chick ever makes you get tested for the Big Louie, make sure to piss in the cup instead of letting them stick that huge q-tip in there, that shit hurts.
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1. The Captain of the Dipshits.
2. someone skilled enough in the art of being a dipshit that they are able to lead other dipshits into ..
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The next game of the Resident Evil games. Its set in the bleak future where zombies have learned that masturbation feels better then eat..
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1. Yet another reference to the vagina.
It's pretty sad when the best sex you're getting isn't even sex at all, and you ..
