What is Big Louie?
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A generic phrase to describe any sexually transmitted disease, or as a shorthand to describe having multiple STDs. Some dispute exists as to the proper spelling, but either "Big Louie" or "Big Louis" is acceptable.
Dude, if a chick ever makes you get tested for the Big Louie, make sure to piss in the cup instead of letting them stick that huge q-tip in there, that shit hurts.
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Random Words:
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Over sized vaginal lips. Or plump labia.
Definition. Noun. Over sized Labia Majora.
Yeah dude, she had a plump biscuit!
See plump, ..
1.
A term used frequently in online chat rooms. When you chat with a girl who puts good angled & photoshopped pictures of herself up t..