Big Louie Edit Meaning

1.

A generic phrase to describe any sexually transmitted disease, or as a shorthand to describe having multiple STDs. Some dispute exists as to the proper spelling, but either "Big Louie" or "Big Louis" is acceptable.

Dude, if a chick ever makes you get tested for the Big Louie, make sure to piss in the cup instead of letting them stick that huge q-tip in there, that shit hurts.

See louie, sexually transmitted disease, std, venereal disease, vd, crabs, hpv, syphilis, hepatitis, herpes, hiv, aids, chlamydia, scabies, ngu, pid, vaginitis