What is Big Louie?
1.
A generic phrase to describe any sexually transmitted disease, or as a shorthand to describe having multiple STDs. Some dispute exists as to the proper spelling, but either "Big Louie" or "Big Louis" is acceptable.
Dude, if a chick ever makes you get tested for the Big Louie, make sure to piss in the cup instead of letting them stick that huge q-tip in there, that shit hurts.
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1.
Where you put a girl head-first into a sleeping bag and then fuck her in the ass.
I used to hate camping, until I gave Rachael the Toas..
1.
That cool band from Cleveland Ohio.
"Novocaine Halo totally rocks my ass!"..